The timing of T cell priming and cycling

The timing of T cell priming and cycling

Blog Article

The proliferation of specific lymphocytes is the central tenet of the clonal selection paradigm.Antigen recognition by T cells triggers a series of events that produces expanded clones of differentiated effector cells.TCR signaling events are detectable within seconds and minutes and are likely to continue for hours and days in vivo.Here, I review the work done on the importance of TCR signals am22 pro model in the later part of the expansion phase of the primary T cell response, primarily regarding the regulation of the cell jolly rancher filled gummies cycle in CD4+ and CD8+ cells.

The results suggest a degree of programming by early signals for effector differentiation, particularly in the CD8+ T cell compartment, with optimal expansion supported by persistent antigen presentation later on.Differences to CD4+ T cell expansion and new avenues towards a molecular understanding of cell cycle regulation in lymphocytes are discussed.